› 8jmz

X-ray diffraction
1.99Å resolution

FGFR1 kinase domain with sulfatinib

Released:
DOI: 10.2210/pdb8jmz/pdb
PDB entry 8jmz coloured by chain, front view.
PDB entry 8jmz coloured by chain, side view.
PDB entry 8jmz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R.
Lin Q, Dai S, Qu L, Lin H, Guo M, Wei H, Chen Y, Chen X
OpenAccess logo Commun Chem 7 3 (2024)
PMID: 38172256

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 310 amino acids
Theoretical weight: 35.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11362 (Residues: 458-765; Coverage: 39%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

3 bound ligands:
Ligand UKI 2 x UKI
Ligand SO4 9 x SO4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: Cu FINE FOCUS
Spacegroup: C2
Unit cell:
a: 211.458Å b: 49.873Å c: 66.691Å
α: 90° β: 107.57° γ: 90°
R-values:
R R work R free
0.166 0.163 0.205
Expression system: Escherichia coli

Quick links

Citations

1 review citation

A glance at structural biology in advancing rice blast fungus research.
Yan et al. (2024)

1 mention without citation

Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R.
Lin et al. (2024)