› 8jn8

X-ray diffraction
1.9Å resolution

Crystal structure of c-Src in complex with covalent inhibitor DC-Srci-6668

Released:
DOI: 10.2210/pdb8jn8/pdb
PDB entry 8jn8 coloured by chain, front view.
PDB entry 8jn8 coloured by chain, side view.
PDB entry 8jn8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhang HM, Luo C

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chain: A
Molecule details ›
Chain: A
Length: 536 amino acids
Theoretical weight: 59.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12931 (Residues: 1-536; Coverage: 100%)
Gene names: SRC, SRC1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand JA6 1 x JA6
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: NFPSS BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 51.189Å b: 82.91Å c: 106.623Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.254
Expression system: Spodoptera frugiperda

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