8jo0

Electron Microscopy
3.6Å resolution

The Cryo-EM structure of a heptameric CED-4/CED-3 catalytic complex

Released:
Source organism: Caenorhabditis elegans
Primary publication:
Structural insights into CED-3 activation.
OpenAccess logo Life Sci Alliance 6 (2023)
PMID: 37402593
Related structures: EMD-36451

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tridecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273518 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cell death protein 4 Chains: H, I, J, K, L, M
Molecule details ›
Chains: H, I, J, K, L, M
Length: 110 amino acids
Theoretical weight: 12.93 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli
UniProt:
  • Canonical: P30429 (Residues: 1-110; Coverage: 20%)
Gene names: C35D10.9, ced-4
Sequence domains: Caspase recruitment domain
Cell death protein 4 Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 549 amino acids
Theoretical weight: 62.95 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli
UniProt:
  • Canonical: P30429 (Residues: 1-549; Coverage: 100%)
Gene names: C35D10.9, ced-4
Sequence domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-36451
Expression system: Escherichia coli