› 8jog

Solution NMR

solution structure of Ras Binding Domein (RBD) in C-RAF with negative allosteric modulator.

Released:
DOI: 10.2210/pdb8jog/pdb
PDB entry 8jog coloured by chain, ensemble of 20 models, front view.
PDB entry 8jog coloured by chain, ensemble of 20 models, side view.
PDB entry 8jog coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Makino Y, Matsumoto S, Yoshikawa Y, Kawamura T, Kumasaka T, Shima F

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137335 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RAF proto-oncogene serine/threonine-protein kinase Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 9.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04049 (Residues: 51-131; Coverage: 13%)
Gene names: RAF, RAF1
Sequence domains: Raf-like Ras-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing
Expression system: Escherichia coli

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