Function and Biology

cryo-EM structure of the CED-4/CED-3 holoenzyme

Source organism: Caenorhabditis elegans
Biochemical function: identical protein binding
Biological process: positive regulation of synapse pruning
Cellular component: perinuclear region of cytoplasm

EC 3.4.22.60: Caspase-7

Reaction catalysed:
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-
Systematic name:
-
Alternative Name(s):
  • Apoptotic protease Mch-3
  • CASP-7
  • CMH-1
  • ICE-LAP3
  • ICE-like apoptotic protease 3
  • Mch3

Sequence families

Pfam Protein families (Pfam)
PF00619
Domain description: Caspase recruitment domain
Occurring in:
  1. Cell death protein 4
  2. Cell death protein 3
The deposited structure of PDB entry 8jol contains 2 copies of Pfam domain PF00619 (Caspase recruitment domain) in Cell death protein 4. Showing 1 copy in chain A.
The deposited structure of PDB entry 8jol contains 1 copy of Pfam domain PF00619 (Caspase recruitment domain) in Cell death protein 3. Showing 1 copy in chain C.

PF22094
Domain description: CED4, winged-helix domain
Occurring in:
  1. Cell death protein 4

PF00931
Domain description: NB-ARC domain
Occurring in:
  1. Cell death protein 4
The deposited structure of PDB entry 8jol contains 2 copies of Pfam domain PF00931 (NB-ARC domain) in Cell death protein 4. Showing 1 copy in chain A.

PF00656
Domain description: Caspase domain
Occurring in:
  1. Cell death protein 3
The deposited structure of PDB entry 8jol contains 1 copy of Pfam domain PF00656 (Caspase domain) in Cell death protein 3. Showing 1 copy in chain C (this domain is out of the observed residue ranges!).