› 8joq

X-ray diffraction
1.8Å resolution

Plk1 polo-box domain bound to HPV18 L2 residues 209-215 with pThr213

Released:
DOI: 10.2210/pdb8joq/pdb
Model geometry
Fit model/data
PDB entry 8joq coloured by chain, front view.
PDB entry 8joq coloured by chain, side view.
PDB entry 8joq coloured by chain, top view.
Source organisms:
Primary publication:
Crystal Structures of Plk1 Polo-Box Domain Bound to the Human Papillomavirus Minor Capsid Protein L2-Derived Peptide.
Jung S, Lee HS, Shin HC, Choi JS, Kim SJ, Ku B
J Microbiol (2023)
PMID: 37684534

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-272374 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase PLK1 Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 26.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53350 (Residues: 371-594; Coverage: 37%)
Gene names: PLK, PLK1
Sequence domains: POLO box duplicated region
Minor capsid protein L2 Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 794 Da
Source organism: human papillomavirus 18
Expression system: Not provided
UniProt:
  • Canonical: P06793 (Residues: 209-215; Coverage: 2%)
Gene name: L2

Ligands and Environments

No bound ligands
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P21
Unit cell:
a: 35.143Å b: 54.346Å c: 57.295Å
α: 90° β: 90.61° γ: 90°
R-values:
R R work R free
0.21 0.206 0.25
Expression systems:
  • Escherichia coli
  • Not provided

Quick links