› 8jpr

Electron Microscopy
3.4Å resolution

Cryo-EM structure of Y553C human ClC-6

Released:
DOI: 10.2210/pdb8jpr/pdb
PDB entry 8jpr coloured by chain, front view.
PDB entry 8jpr coloured by chain, side view.
PDB entry 8jpr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of ClC-6 function and its impairment in human disease
Zhang SS
Sci Adv (2023)
Related structures: EMD-36487

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-229152 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
H(+)/Cl(-) exchange transporter 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 869 amino acids
Theoretical weight: 97.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P51797 (Residues: 1-869; Coverage: 100%)
Gene names: CLCN6, KIAA0046
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand CL 4 x CL
Ligand MG 2 x MG
Ligand ATP 2 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-36487
Expression system: Homo sapiens

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