8jr0

Electron Microscopy
2.8Å resolution

Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in complex with TBAJ-587

Released:

Function and Biology Details

Reaction catalysed:
ATP + H(2)O + 4 H(+)(Side 1) = ADP + phosphate + 4 H(+)(Side 2)

Structure analysis Details

Assembly composition:
hetero icosamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246407 (preferred)
Entry contents:
8 distinct polypeptide molecules
Macromolecules (8 distinct):
ATP synthase subunit alpha Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 549 amino acids
Theoretical weight: 59.36 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WPU7 (Residues: 1-549; Coverage: 100%)
Gene names: MTCY373.28, Rv1308, atpA
Sequence domains:
ATP synthase subunit beta Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 486 amino acids
Theoretical weight: 53.15 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WPU5 (Residues: 1-486; Coverage: 100%)
Gene names: MTCY373.30, Rv1310, atpD
Sequence domains:
ATP synthase gamma chain Chain: G
Molecule details ›
Chain: G
Length: 305 amino acids
Theoretical weight: 33.93 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WPU9 (Residues: 1-305; Coverage: 100%)
Gene names: MTCY373.29, Rv1309, atpG
Sequence domains: ATP synthase
ATP synthase epsilon chain Chain: H
Molecule details ›
Chain: H
Length: 121 amino acids
Theoretical weight: 13.15 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WPV1 (Residues: 1-121; Coverage: 100%)
Gene names: MTCY373.31, Rv1311, atpC
Sequence domains: ATP synthase, Delta/Epsilon chain, beta-sandwich domain
ATP synthase subunit c Chains: 1, 2, 3, 4, 5, 6, 7, 8, 9
Molecule details ›
Chains: 1, 2, 3, 4, 5, 6, 7, 8, 9
Length: 81 amino acids
Theoretical weight: 8.06 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WPS1 (Residues: 1-81; Coverage: 100%)
Gene names: MTCY373.25, Rv1305, atpE
Sequence domains: ATP synthase subunit C
ATP synthase subunit a Chain: a
Molecule details ›
Chain: a
Length: 250 amino acids
Theoretical weight: 27.49 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WPV7 (Residues: 1-250; Coverage: 100%)
Gene names: MTCY373.24, Rv1304, atpB
Sequence domains: ATP synthase A chain
ATP synthase subunit b Chain: b
Molecule details ›
Chain: b
Length: 171 amino acids
Theoretical weight: 18.35 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WPV5 (Residues: 1-171; Coverage: 100%)
Gene names: MTCY373.26, Rv1306, atpF
Sequence domains: ATP synthase B/B' CF(0)
ATP synthase subunit b-delta Chain: d
Molecule details ›
Chain: d
Length: 446 amino acids
Theoretical weight: 48.87 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WPV3 (Residues: 1-446; Coverage: 100%)
Gene names: MTCY373.27, Rv1307, atpF, atpFH, atpH
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-36589
Expression system: Mycolicibacterium smegmatis