› 8jre

Electron Microscopy
2.08Å resolution

Cryo-EM structure of a designed AAV8-based vector

Released:
DOI: 10.2210/pdb8jre/pdb
PDB entry 8jre coloured by chain, front view.
PDB entry 8jre coloured by chain, side view.
PDB entry 8jre coloured by chain, top view.
Source organism: adeno-associated virus 8
Primary publication:
An adeno-associated virus variant enabling efficient ocular-directed gene delivery across species.
Luo S, Jiang H, Li Q, Qin Y, Yang S, Li J, Xu L, Gou Y, Zhang Y, Liu F, Ke X, Zheng Q, Sun X
OpenAccess logo Nat Commun 15 3780 (2024)
PMID: 38710714
Related structures: EMD-36594

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185014 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein Chains: 1, 2, 3, 4, 5, 6, 7, 8, 9, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y, z
Molecule details ›
Chains: 1, 2, 3, 4, 5, 6, 7, 8, 9, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y, z
Length: 526 amino acids
Theoretical weight: 59.27 KDa
Source organism: adeno-associated virus 8
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8JQF8 (Residues: 218-587, 588-592, 593-738; Coverage: 71%)
Sequence domains: Parvovirus coat protein VP2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.08Å
Relevant EMDB volumes: EMD-36594
Expression system: Homo sapiens

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