EC 3.4.21.69: Protein C (activated)
Reaction catalysed:
Degradation of blood coagulation factors Va and VIIIa.
Systematic name:
-
Alternative Name(s):
- APC
- Activated blood coagulation factor XIV
- Activated protein C
- Autoprothrombin II-A
- Autoprothrombin IIA
- Blood-coagulation factor XIVa
- GSAPC
- Protein Ca
GO terms
Biochemical function:
Biological process:
- clathrin-dependent endocytosis
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of Notch signaling pathway
- receptor internalization
- protein transport
- negative regulation of signal transduction
- visual perception
- signal transduction
- ubiquitin-dependent protein catabolic process
- positive regulation of receptor internalization
- G protein-coupled receptor internalization
- desensitization of G protein-coupled receptor signaling pathway
- positive regulation of protein phosphorylation
Protein families (Pfam)![The deposited structure of PDB entry 8jru contains 1 copy of Pfam domain PF00002 (7 transmembrane receptor (Secretin family)) in Activation peptide. Showing 1 copy in chain A [auth R].](https://www.ebi.ac.uk/pdbe/static/entry/8jru_1_R_Pfam_PF00002_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>8jru</span> contains 1 copy of Pfam domain <span class='highlight'>PF00002 (7 transmembrane receptor (Secretin family))</span> in <span class='highlight'>Activation peptide</span>. Showing 1 copy in chain <span class='highlight'>A [auth R]</span>.")
![The deposited structure of PDB entry 8jru contains 1 copy of Pfam domain PF02793 (Hormone receptor domain) in Activation peptide. Showing 1 copy in chain A [auth R] (this domain is out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/8jru_1_R_Pfam_PF02793_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>8jru</span> contains 1 copy of Pfam domain <span class='highlight'>PF02793 (Hormone receptor domain)</span> in <span class='highlight'>Activation peptide</span>. Showing 1 copy in chain <span class='highlight'>A [auth R]</span> (this domain is out of the observed residue ranges!).")