› 8jt9

Electron Microscopy
2.97Å resolution

Human VMAT2 complex with ketanserin

Released:
DOI: 10.2210/pdb8jt9/pdb
PDB entry 8jt9 coloured by chain, front view.
PDB entry 8jt9 coloured by chain, side view.
PDB entry 8jt9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transport and inhibition mechanisms of human VMAT2.
Wu D, Chen Q, Yu Z, Huang B, Zhao J, Wang Y, Su J, Zhou F, Yan R, Li N, Zhao Y, Jiang D
Nature (2023)
PMID: 38081299
Related structures: EMD-36637

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-233030 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptic vesicular amine transporter Chain: A
Molecule details ›
Chain: A
Length: 457 amino acids
Theoretical weight: 49.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05940 (Residues: 18-474; Coverage: 89%)
Gene names: SLC18A2, SVMT, VMAT2
Sequence domains: Major Facilitator Superfamily

Ligands and Environments

1 bound ligand:
Ligand UYX 1 x UYX
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.97Å
Relevant EMDB volumes: EMD-36637
Expression system: Homo sapiens

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