› 8jtd

Electron Microscopy
4.9Å resolution

BJOX2000.664 trimer in complex with Fab fragment of broadly neutralizing HIV antibody PGT145

Released:
DOI: 10.2210/pdb8jtd/pdb
PDB entry 8jtd coloured by chain, front view.
PDB entry 8jtd coloured by chain, side view.
PDB entry 8jtd coloured by chain, top view.
Source organisms:
Primary publication:
An HIV-1 broadly neutralizing antibody overcomes structural and dynamic variation through highly focused epitope targeting.
Hodge EA, Chatterjee A, Chen C, Naika GS, Laohajaratsang M, Mangala Prasad V, Lee KK
OpenAccess logo Npj Viruses 1 2 (2023)
PMID: 38665238
Related structures: EMD-36641

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-240914 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (10 distinct):
Envelope glycoprotein gp160 Chains: A, C, D
Molecule details ›
Chains: A, C, D
Length: 481 amino acids
Theoretical weight: 54.06 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 30-508; Coverage: 56%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Transmembrane protein gp41 Chains: B, E, F
Molecule details ›
Chains: B, E, F
Length: 153 amino acids
Theoretical weight: 17.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 509-661; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
PGT145 antibody fragment, heavy chain Chain: J
Molecule details ›
Chain: J
Length: 267 amino acids
Theoretical weight: 28.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
PGT145 antibody fragment, light chain Chain: N
Molecule details ›
Chain: N
Length: 219 amino acids
Theoretical weight: 23.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 20 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.9Å
Relevant EMDB volumes: EMD-36641
Expression system: Homo sapiens

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