› 8jun

Electron Microscopy
2.38Å resolution

Cryo-EM structure of SIDT1 E555Q mutant

Released:
DOI: 10.2210/pdb8jun/pdb
PDB entry 8jun coloured by chain, front view.
PDB entry 8jun coloured by chain, side view.
PDB entry 8jun coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human SIDT1 mediates dsRNA uptake via its phospholipase activity.
Sun CR, Xu D, Yang F, Hou Z, Luo Y, Zhang CY, Shan G, Huang G, Yao X, Chen Y, Li Q, Zhou CZ
Cell Res (2023)
PMID: 37932444
Related structures: EMD-36662

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-235962 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SID1 transmembrane family member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 827 amino acids
Theoretical weight: 93.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NXL6 (Residues: 1-827; Coverage: 100%)
Gene name: SIDT1
Sequence domains: dsRNA-gated channel SID-1

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand POV 2 x POV
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.38Å
Relevant EMDB volumes: EMD-36662
Expression system: Homo sapiens

Quick links

Citations

1 mention without citation

Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain.
Navratna et al. (2023)