› 8jv5

Electron Microscopy
3.23Å resolution

Cryo-EM structure of the zebrafish P2X4 receptor in complex with BX430

Released:
DOI: 10.2210/pdb8jv5/pdb
PDB entry 8jv5 coloured by chain, front view.
PDB entry 8jv5 coloured by chain, side view.
PDB entry 8jv5 coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Structural insights into the allosteric inhibition of P2X4 receptors.
Shen C, Zhang Y, Cui W, Zhao Y, Sheng D, Teng X, Shao M, Ichikawa M, Wang J, Hattori M
OpenAccess logo Nat Commun 14 6437 (2023)
PMID: 37833294
Related structures: EMD-36668

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-244872 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P2X purinoceptor 4a Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 351 amino acids
Theoretical weight: 39.48 KDa
Source organism: Danio rerio
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: F8W463 (Residues: 9-359; Coverage: 90%)
Gene name: p2rx4a
Sequence domains: ATP P2X receptor

Ligands and Environments

2 bound ligands:
Ligand P73 3 x P73
Ligand NAG 9 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.23Å
Relevant EMDB volumes: EMD-36668
Expression system: Spodoptera frugiperda

Quick links

Citations

1 mention without citation

Structural insights into the allosteric inhibition of P2X4 receptors.
Shen et al. (2023)