› 8jvj

Electron Microscopy
3.44Å resolution

Structure of human TRPV4 with antagonist A2 and RhoA

Released:
DOI: 10.2210/pdb8jvj/pdb
PDB entry 8jvj coloured by chain, front view.
PDB entry 8jvj coloured by chain, side view.
PDB entry 8jvj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Pharmacology of TRPV4 Antagonists.
Fan J, Guo C, Liao D, Ke H, Lei J, Xie W, Tang Y, Tominaga M, Huang Z, Lei X
OpenAccess logo Adv Sci (Weinh) e2401583 (2024)
PMID: 38659239
Related structures: EMD-36676

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-221249 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transient receptor potential cation channel subfamily V member 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1144 amino acids
Theoretical weight: 128.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9HBA0 (Residues: 1-871; Coverage: 100%)
Gene names: TRPV4, VRL2, VROAC
Sequence domains:
Transforming protein RhoA Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 193 amino acids
Theoretical weight: 21.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61586 (Residues: 1-193; Coverage: 100%)
Gene names: ARH12, ARHA, RHO12, RHOA
Sequence domains: Ras family

Ligands and Environments

1 bound ligand:
Ligand F9M 4 x F9M
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.44Å
Relevant EMDB volumes: EMD-36676
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Structural Pharmacology of TRPV4 Antagonists.
Fan et al. (2024)