› 8jwi

Electron Microscopy
2.94Å resolution

Cryo-EM structure of the outward-facing Plasmodium falciparum multidrug resistance protein 1

Released:
DOI: 10.2210/pdb8jwi/pdb
PDB entry 8jwi coloured by chain, front view.
PDB entry 8jwi coloured by chain, side view.
PDB entry 8jwi coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain.
Si K, He X, Chen L, Zhang A, Guo C, Li M
Proc Natl Acad Sci U S A 120 e2219905120 (2023)
PMID: 37527341
Related structures: EMD-36684

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-227926 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Multidrug resistance protein 1 Chain: A
Molecule details ›
Chain: A
Length: 1387 amino acids
Theoretical weight: 158.42 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q7K6A5 (Residues: 38-1419; Coverage: 97%)
Gene name: PF3D7_0523000
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ATP 2 x ATP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.94Å
Relevant EMDB volumes: EMD-36684
Expression system: Spodoptera frugiperda

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