› 8k0b

Electron Microscopy
3.56Å resolution

Cryo-EM structure of TMEM63C

Released:
DOI: 10.2210/pdb8k0b/pdb
PDB entry 8k0b coloured by chain, front view.
PDB entry 8k0b coloured by chain, side view.
PDB entry 8k0b coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Cryo-EM structure of TMEM63C suggests it functions as a monomer.
Qin Y, Yu D, Wu D, Dong J, Li WT, Ye C, Cheung KC, Zhang Y, Xu Y, Wang Y, Shi YS, Dang S
Nat Commun 14 7265 (2023)
PMID: 37945568
Related structures: EMD-36759

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236366 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium permeable stress-gated cation channel 1 Chain: A
Molecule details ›
Chain: A
Length: 802 amino acids
Theoretical weight: 93.11 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8CBX0 (Residues: 1-802; Coverage: 100%)
Gene names: CSC1, Tmem63c
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.56Å
Relevant EMDB volumes: EMD-36759
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons.
Yang et al. (2024)