› 8k0d

Electron Microscopy
2.94Å resolution

Cryo-EM structure of conformation 2 of complex of Nipah virus attachment G with 1E5 neutralizing antibody

Released:
DOI: 10.2210/pdb8k0d/pdb
PDB entry 8k0d coloured by chain, front view.
PDB entry 8k0d coloured by chain, side view.
PDB entry 8k0d coloured by chain, top view.
Source organism: Macaca mulatta
Primary publication:
A potent Henipavirus cross-neutralizing antibody reveals a dynamic fusion-triggering pattern of the G-tetramer.
Fan P, Sun M, Zhang X, Zhang H, Liu Y, Yao Y, Li M, Fang T, Sun B, Chen Z, Chi X, Chen L, Peng C, Chen Z, Zhang G, Ren Y, Liu Z, Li Y, Li J, Li E, Guan W, Li S, Gong R, Zhang K, Yu C, Chiu S
OpenAccess logo Nat Commun 15 4330 (2024)
PMID: 38773072
Related structures: EMD-36761

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243825 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
The heavy chain of 1E5 Chains: C, E
Molecule details ›
Chains: C, E
Length: 242 amino acids
Theoretical weight: 26.12 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
The light chain of 1E5 Chains: D, F
Molecule details ›
Chains: D, F
Length: 213 amino acids
Theoretical weight: 23.08 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
Glycoprotein G Chains: A, B
Molecule details ›
Chains: A, B
Length: 402 amino acids
Theoretical weight: 45.23 KDa
UniProt:
  • Canonical: Q9IH62 (Residues: 200-601; Coverage: 67%)
Gene name: G
Sequence domains: Haemagglutinin-neuraminidase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.94Å
Relevant EMDB volumes: EMD-36761
Expression system: Homo sapiens

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