› 8k3c

Electron Microscopy
2.88Å resolution

Nipah virus Attachment glycoprotein with 41-6 antibody fragment

Released:
DOI: 10.2210/pdb8k3c/pdb
PDB entry 8k3c coloured by chain, front view.
PDB entry 8k3c coloured by chain, side view.
PDB entry 8k3c coloured by chain, top view.
Source organisms:
Primary publication:
Potent human neutralizing antibodies against Nipah virus derived from two ancestral antibody heavy chains.
Chen L, Sun M, Zhang H, Zhang X, Yao Y, Li M, Li K, Fan P, Zhang H, Qin Y, Zhang Z, Li E, Chen Z, Guan W, Li S, Yu C, Zhang K, Gong R, Chiu S
OpenAccess logo Nat Commun 15 2987 (2024)
PMID: 38582870
Related structures: EMD-36849

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243826 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Light chain of 41-6 Fab fragment Chain: D
Molecule details ›
Chain: D
Length: 216 amino acids
Theoretical weight: 22.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Heavy chain of 41-6 Fab fragments Chain: C
Molecule details ›
Chain: C
Length: 238 amino acids
Theoretical weight: 25.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Glycoprotein G Chains: A, B
Molecule details ›
Chains: A, B
Length: 471 amino acids
Theoretical weight: 52.94 KDa
Source organism: Henipavirus nipahense
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9IH62 (Residues: 131-601; Coverage: 78%)
Gene name: G
Sequence domains: Haemagglutinin-neuraminidase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.88Å
Relevant EMDB volumes: EMD-36849
Expression systems:
  • Escherichia coli
  • Homo sapiens

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