Function and Biology

The "5+1" heteromeric structure of Lon protease consisting of a spiral pentamer with Y224S mutation and an N-terminal-truncated monomeric E613K mutant

Source organism: Meiothermus taiwanensis
Biochemical function: ATP hydrolysis activity
Biological process: protein catabolic process
Cellular component: cytoplasm

EC 3.4.21.53: Endopeptidase La

Reaction catalysed:
Hydrolysis of proteins in presence of ATP.
Alternative Name(s):
  • ATP-dependent lon proteinase
  • ATP-dependent protease La
  • ATP-dependent serine proteinase
  • Escherichia coli proteinase La
  • Escherichia coli serine proteinase La
  • Gene lon protease
  • Gene lon proteins
  • Lon proteinase
  • PIM1 protease
  • PIM1 proteinase
  • Protease La
  • Proteinase La
  • Serine protease La

Sequence families

Pfam Protein families (Pfam)
PF05362
Domain description: Lon protease (S16) C-terminal proteolytic domain
Occurring in:
  1. Lon protease
  2. Lon protease
The deposited structure of PDB entry 8k3y contains 5 copies of Pfam domain PF05362 (Lon protease (S16) C-terminal proteolytic domain) in Lon protease. Showing 1 copy in chain A.
The deposited structure of PDB entry 8k3y contains 1 copy of Pfam domain PF05362 (Lon protease (S16) C-terminal proteolytic domain) in Lon protease. Showing 1 copy in chain F.

PF22667
Domain description: Lon protease AAA+ ATPase lid domain
Occurring in:
  1. Lon protease
  2. Lon protease

PF00004
Domain description: ATPase family associated with various cellular activities (AAA)
Occurring in:
  1. Lon protease
  2. Lon protease
The deposited structure of PDB entry 8k3y contains 5 copies of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in Lon protease. Showing 1 copy in chain A.
The deposited structure of PDB entry 8k3y contains 1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in Lon protease. Showing 1 copy in chain F.

PF02190
Domain description: ATP-dependent protease La (LON) substrate-binding domain
Occurring in:
  1. Lon protease
The deposited structure of PDB entry 8k3y contains 5 copies of Pfam domain PF02190 (ATP-dependent protease La (LON) substrate-binding domain ) in Lon protease. Showing 1 copy in chain A.