› 8k6p

X-ray diffraction
1.86Å resolution

Crystal structure of SHARPIN LTM motif

Released:
DOI: 10.2210/pdb8k6p/pdb
PDB entry 8k6p coloured by chain, front view.
PDB entry 8k6p coloured by chain, side view.
PDB entry 8k6p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN.
Zhang Y, Xu X, Wang Y, Wang Y, Zhou X, Pan L
Biochem Biophys Res Commun 689 149239 (2023)
PMID: 37976837

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190476 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sharpin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 48 amino acids
Theoretical weight: 4.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H0F6 (Residues: 164-210; Coverage: 12%)
Gene names: PSEC0216, SHARPIN, SIPL1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL02U1
Spacegroup: C2
Unit cell:
a: 99.38Å b: 39.24Å c: 31.35Å
α: 90° β: 97.041° γ: 90°
R-values:
R R work R free
0.221 0.218 0.277
Expression system: Escherichia coli

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