› 8k8t

Electron Microscopy
3.8Å resolution

Structure of CUL3-RBX1-KLHL22 complex

Released:
DOI: 10.2210/pdb8k8t/pdb
PDB entry 8k8t coloured by chain, front view.
PDB entry 8k8t coloured by chain, side view.
PDB entry 8k8t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3KLHL22.
Wang W, Liang L, Dai Z, Zuo P, Yu S, Lu Y, Ding D, Chen H, Shan H, Jin Y, Mao Y, Yin Y
OpenAccess logo Nat Commun 15 3789 (2024)
PMID: 38710693
Related structures: EMD-36961

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274533 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cullin-3 Chains: C, D
Molecule details ›
Chains: C, D
Length: 776 amino acids
Theoretical weight: 90.13 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13618 (Residues: 1-768; Coverage: 100%)
Gene names: CUL3, KIAA0617
Sequence domains:
Kelch-like protein 22 Chains: K, L
Molecule details ›
Chains: K, L
Length: 660 amino acids
Theoretical weight: 74.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q53GT1 (Residues: 1-634; Coverage: 100%)
Gene name: KLHL22
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-36961
Expression system: Spodoptera frugiperda

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