The deposited structure of PDB entry 8kco coloured by chain, front view. This structure contains:
- 1 copy of Nicastrin;
- 1 copy of Presenilin-1;
- 1 copy of Gamma-secretase subunit APH-1A;
- 1 copy of Gamma-secretase subunit PEN-2;
- 5 copies of 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose;
- 1 copy of beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose;
- 6 copies of 2-acetamido-2-deoxy-beta-D-glucopyranose;
- 1 copy of 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide;
- 2 copies of 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE;
- 3 copies of CHOLESTEROL.
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>8kco</span> coloured by chain, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>Nicastrin</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Presenilin-1</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit APH-1A</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit PEN-2</span>;</li> <li class='image_legend_li'>5 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>6 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>CHOLESTEROL</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8kco_deposited_chain_side_image-800x800.png "PDB entry 8kco coloured by chain, side view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>8kco</span> coloured by chain, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>Nicastrin</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Presenilin-1</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit APH-1A</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit PEN-2</span>;</li> <li class='image_legend_li'>5 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>6 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>CHOLESTEROL</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8kco_deposited_chain_top_image-800x800.png "PDB entry 8kco coloured by chain, top view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>8kco</span> coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>Nicastrin</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Presenilin-1</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit APH-1A</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit PEN-2</span>;</li> <li class='image_legend_li'>5 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>6 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>CHOLESTEROL</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8kco_deposited_chemically_distinct_molecules_front_image-800x800.png "PDB entry 8kco coloured by chemically distinct molecules, front view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>8kco</span> coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>Nicastrin</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Presenilin-1</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit APH-1A</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit PEN-2</span>;</li> <li class='image_legend_li'>5 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>6 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>CHOLESTEROL</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8kco_deposited_chemically_distinct_molecules_side_image-800x800.png "PDB entry 8kco coloured by chemically distinct molecules, side view.")
![<div class='caption-body'>The deposited structure of PDB entry <span class='highlight'>8kco</span> coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>Nicastrin</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Presenilin-1</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit APH-1A</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit PEN-2</span>;</li> <li class='image_legend_li'>5 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>6 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>CHOLESTEROL</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8kco_deposited_chemically_distinct_molecules_top_image-800x800.png "PDB entry 8kco coloured by chemically distinct molecules, top view.")
![<div class='caption-body'>Hetero tetrameric assembly 1 of PDB entry <span class='highlight'>8kco</span> contains 1 copy of <span class='highlight'>beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>. Front view.</div>](https://www.ebi.ac.uk/pdbe/static/entry/8kco_entity_6_front_image-800x800.png "beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose in PDB entry 8kco, assembly 1, front view.")
![<div class='caption-body'>Hetero tetrameric assembly 1 of PDB entry <span class='highlight'>8kco</span> contains 1 copy of <span class='highlight'>2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide</span>. Front view.</div>](https://www.ebi.ac.uk/pdbe/static/entry/8kco_entity_8_front_image-800x800.png "2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide in PDB entry 8kco, assembly 1, front view.")
![<div class='caption-body'>Hetero tetrameric assembly 1 of PDB entry <span class='highlight'>8kco</span> coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>Nicastrin</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Presenilin-1</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit APH-1A</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit PEN-2</span>;</li> <li class='image_legend_li'>5 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>6 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>CHOLESTEROL</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8kco_assembly_1_chemically_distinct_molecules_front_image-800x800.png "Hetero tetrameric assembly 1 of PDB entry 8kco coloured by chemically distinct molecules, front view.")
![<div class='caption-body'>Hetero tetrameric assembly 1 of PDB entry <span class='highlight'>8kco</span> coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>Nicastrin</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Presenilin-1</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit APH-1A</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit PEN-2</span>;</li> <li class='image_legend_li'>5 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>6 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>CHOLESTEROL</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8kco_assembly_1_chemically_distinct_molecules_side_image-800x800.png "Hetero tetrameric assembly 1 of PDB entry 8kco coloured by chemically distinct molecules, side view.")
![<div class='caption-body'>Hetero tetrameric assembly 1 of PDB entry <span class='highlight'>8kco</span> coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of <span class='highlight'>Nicastrin</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Presenilin-1</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit APH-1A</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>Gamma-secretase subunit PEN-2</span>;</li> <li class='image_legend_li'>5 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>6 copies of <span class='highlight'>2-acetamido-2-deoxy-beta-D-glucopyranose</span>;</li> <li class='image_legend_li'>1 copy of <span class='highlight'>2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide</span>;</li> <li class='image_legend_li'>2 copies of <span class='highlight'>1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE</span>;</li> <li class='image_legend_li'>3 copies of <span class='highlight'>CHOLESTEROL</span>.</li></ul></div>](https://www.ebi.ac.uk/pdbe/static/entry/8kco_assembly_1_chemically_distinct_molecules_top_image-800x800.png "Hetero tetrameric assembly 1 of PDB entry 8kco coloured by chemically distinct molecules, top view.")
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