› 8kdh

Electron Microscopy
3.78Å resolution

Structure of LAT1-CD98hc in complex with BCH, focused on TMD

Released:
DOI: 10.2210/pdb8kdh/pdb
PDB entry 8kdh coloured by chain, front view.
PDB entry 8kdh coloured by chain, side view.
PDB entry 8kdh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of anticancer drug recognition and amino acid transport by LAT1.
Lee Y, Jin C, Ohgaki R, Xu M, Ogasawara S, Warshamanage R, Yamashita K, Murshudov G, Nureki O, Murata T, Kanai Y
Nat Commun 16 1635 (2025)
PMID: 39952931
Related structures: EMD-37136

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140015 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Amino acid transporter heavy chain SLC3A2 Chain: A
Molecule details ›
Chain: A
Length: 631 amino acids
Theoretical weight: 68.07 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08195 (Residues: 2-630; Coverage: 100%)
Gene names: MDU1, SLC3A2
Sequence domains:
Large neutral amino acids transporter small subunit 1 Chain: B
Molecule details ›
Chain: B
Length: 515 amino acids
Theoretical weight: 56.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q01650 (Residues: 1-507; Coverage: 100%)
Gene names: CD98LC, LAT1, MPE16, SLC7A5
Sequence domains: Amino acid permease

Ligands and Environments

3 bound ligands:
Ligand CLR 2 x CLR
Ligand LBN 1 x LBN
Ligand VU0 1 x VU0
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.78Å
Relevant EMDB volumes: EMD-37136
Expression system: Homo sapiens

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