8kes

Electron Microscopy
3.5Å resolution

Cryo-EM structure of human complex B

Released:
Source organism: Homo sapiens
Entry authors: Qian HW, He JJ
Related structures: EMD-37166

Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-286059 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
E3 ubiquitin-protein ligase synoviolin Chains: A, B
Molecule details ›
Chains: A, B
Length: 617 amino acids
Theoretical weight: 67.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q86TM6 (Residues: 1-617; Coverage: 100%)
Gene names: HRD1, KIAA1810, SYVN1
Sequence domains: Ring finger domain
Protein sel-1 homolog 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 794 amino acids
Theoretical weight: 88.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UBV2 (Residues: 1-794; Coverage: 100%)
Gene names: SEL1L, TSA305, UNQ128/PRO1063
Sequence domains:
Endoplasmic reticulum lectin 1 Chains: E, F
Ala-Asn-Ala Chains: G, H

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-37166
Expression system: Homo sapiens