› 8kfd

X-ray diffraction
1.8Å resolution

Ferritin drug carrier(FDC) for encapsulated platinum (IV) prodrug for esophageal squamous cell carcinoma targeted therapy

Released:
DOI: 10.2210/pdb8kfd/pdb
PDB entry 8kfd coloured by chain, front view.
PDB entry 8kfd coloured by chain, side view.
PDB entry 8kfd coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Chen X

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin heavy chain Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02794 (Residues: 2-183; Coverage: 100%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain

Ligands and Environments

5 bound ligands:
Ligand PT 1 x PT
Ligand GOL 3 x GOL
Ligand CA 1 x CA
Ligand CL 12 x CL
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL02U1
Spacegroup: F432
Unit cell:
a: 183.45Å b: 183.45Å c: 183.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.153 0.166
Expression system: Escherichia coli BL21(DE3)

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