Function and Biology Details
Reactions catalysed:
ATP + H(2)O = ADP + phosphate
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236221 (preferred)
Entry contents:
14 distinct polypeptide molecules
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (16 distinct):
DNA replication licensing factor MCM2
Chain: 2
Molecule details ›
Chain: 2
Length: 868 amino acids
Theoretical weight: 98.91 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 868 amino acids
Theoretical weight: 98.91 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
P29469 (Residues: 1-868; Coverage: 100%)
Sequence domains:
DNA replication licensing factor MCM3
Chain: 3
Molecule details ›
Chain: 3
Length: 971 amino acids
Theoretical weight: 107.65 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 971 amino acids
Theoretical weight: 107.65 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
P24279 (Residues: 1-971; Coverage: 100%)
Sequence domains:
DNA replication licensing factor MCM4
Chain: 4
Molecule details ›
Minichromosome maintenance protein 5
Chain: 5
Molecule details ›
DNA replication licensing factor MCM6
Chain: 6
Molecule details ›
Chain: 6
Length: 1017 amino acids
Theoretical weight: 113.11 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 1017 amino acids
Theoretical weight: 113.11 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
P53091 (Residues: 1-1017; Coverage: 100%)
Sequence domains:
DNA replication licensing factor MCM7
Chain: 7
Molecule details ›
DNA replication complex GINS protein PSF1
Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 24.23 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains: GINS complex protein helical bundle domain
Length: 208 amino acids
Theoretical weight: 24.23 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
Q12488 (Residues: 1-208; Coverage: 100%)
Sequence domains: GINS complex protein helical bundle domain
DNA replication complex GINS protein PSF2
Chain: B
Molecule details ›
Chain: B
Length: 213 amino acids
Theoretical weight: 25.1 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains: GINS complex protein helical bundle domain
Length: 213 amino acids
Theoretical weight: 25.1 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
P40359 (Residues: 1-213; Coverage: 100%)
Sequence domains: GINS complex protein helical bundle domain
DNA replication complex GINS protein PSF3
Chain: C
Molecule details ›
Chain: C
Length: 194 amino acids
Theoretical weight: 21.98 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 194 amino acids
Theoretical weight: 21.98 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
Q12146 (Residues: 1-194; Coverage: 100%)
Sequence domains:
DNA replication complex GINS protein SLD5
Chain: D
Molecule details ›
Chain: D
Length: 294 amino acids
Theoretical weight: 33.98 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 294 amino acids
Theoretical weight: 33.98 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
Q03406 (Residues: 1-294; Coverage: 100%)
Sequence domains:
Cell division control protein 45
Chain: E
Molecule details ›
Chain: E
Length: 650 amino acids
Theoretical weight: 74.32 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains: CDC45-like protein
Length: 650 amino acids
Theoretical weight: 74.32 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
Q08032 (Residues: 1-650; Coverage: 100%)
Sequence domains: CDC45-like protein
DNA polymerase alpha-binding protein
Chains: F, G, H
Molecule details ›
DNA polymerase epsilon catalytic subunit A
Chain: M
Molecule details ›
DNA polymerase epsilon subunit B
Chain: N
Molecule details ›
Chain: N
Length: 689 amino acids
Theoretical weight: 78.43 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains: DNA polymerase alpha/epsilon subunit B
Length: 689 amino acids
Theoretical weight: 78.43 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
P24482 (Residues: 1-689; Coverage: 100%)
Sequence domains: DNA polymerase alpha/epsilon subunit B
DNA (71-mer)
Chain: I
Molecule details ›
Chain: I
Length: 71 nucleotides
Theoretical weight: 22.14 KDa
Length: 71 nucleotides
Theoretical weight: 22.14 KDa
DNA (61-mer)
Chain: J
Molecule details ›
Chain: J
Length: 61 nucleotides
Theoretical weight: 18.52 KDa
Length: 61 nucleotides
Theoretical weight: 18.52 KDa