8ki3

Electron Microscopy
2.89Å resolution

Structure of the human ATP synthase bound to bedaquiline (composite)

Released:
Source organism: Homo sapiens
Related structures: EMD-37251

Function and Biology Details

Reaction catalysed:
ATP + H(2)O + 4 H(+)(Side 1) = ADP + phosphate + 4 H(+)(Side 2)

Structure analysis Details

Assembly composition:
hetero 28-mer (preferred)
PDBe Complex ID:
PDB-CPX-271868 (preferred)
Entry contents:
17 distinct polypeptide molecules
Macromolecules (17 distinct):
ATP synthase subunit alpha, mitochondrial Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 510 amino acids
Theoretical weight: 55.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25705 (Residues: 44-553; Coverage: 92%)
Gene names: ATP5A, ATP5A1, ATP5AL2, ATP5F1A, ATPM
Sequence domains:
ATP synthase subunit beta, mitochondrial Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 482 amino acids
Theoretical weight: 51.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P06576 (Residues: 48-529; Coverage: 91%)
Gene names: ATP5B, ATP5F1B, ATPMB, ATPSB
Sequence domains:
ATP synthase subunit gamma, mitochondrial Chain: G
ATPase inhibitor, mitochondrial Chain: J
ATP synthase subunit O, mitochondrial Chain: O
ATP synthase F(0) complex subunit C1, mitochondrial Chains: 1, 2, 3, 4, 5, 6, 7, 8
ATP synthase subunit delta, mitochondrial Chain: H
ATP synthase subunit epsilon, mitochondrial Chain: I
ATP synthase F(0) complex subunit B1, mitochondrial Chain: K
ATP synthase subunit d, mitochondrial Chain: M
ATP synthase subunit a Chain: N
ATP synthase subunit ATP5MJ, mitochondrial Chain: P
ATP synthase protein 8 Chain: Q
ATP synthase subunit f, mitochondrial Chain: R
ATP synthase subunit g, mitochondrial Chain: S
ATP synthase subunit e, mitochondrial Chain: T
ATP synthase-coupling factor 6, mitochondrial Chain: L

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.89Å
Relevant EMDB volumes: EMD-37251