› 8ofi

Electron Microscopy
3.6Å resolution

Ivabradine bound to HCN4 channel

Released:
DOI: 10.2210/pdb8ofi/pdb
PDB entry 8ofi coloured by chain, front view.
PDB entry 8ofi coloured by chain, side view.
PDB entry 8ofi coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structural determinants of ivabradine block of the open pore of HCN4.
Saponaro A, Krumbach JH, Chaves-Sanjuan A, Sharifzadeh AS, Porro A, Castelli R, Hamacher K, Bolognesi M, DiFrancesco D, Clarke OB, Thiel G, Moroni A
Proc Natl Acad Sci U S A 121 e2402259121 (2024)
PMID: 38917012
Related structures: EMD-16860

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193583 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 892 amino acids
Theoretical weight: 98.52 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9TV66 (Residues: 1-1175; Coverage: 76%)
Gene names: HAC4, HCN4
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand VNZ 1 x VNZ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-16860
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Structural determinants of ivabradine block of the open pore of HCN4.
Saponaro et al. (2024)