› 8ogx

X-ray diffraction
2Å resolution

Beta-glucuronidase from Acidobacterium capsulatum in complex with inhibitor R3794

Released:
DOI: 10.2210/pdb8ogx/pdb
PDB entry 8ogx coloured by chain, front view.
PDB entry 8ogx coloured by chain, side view.
PDB entry 8ogx coloured by chain, top view.
Source organism: Acidobacterium capsulatum
Primary publication:
Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B.
Chen Y, van den Nieuwendijk AMCH, Wu L, Moran E, Skoulikopoulou F, van Riet V, Overkleeft HS, Davies GJ, Armstrong Z
OpenAccess logo J Am Chem Soc (2023)
PMID: 38118176

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111104 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-glucuronidase C-terminal domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 475 amino acids
Theoretical weight: 50.81 KDa
Source organism: Acidobacterium capsulatum
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: C1F2K5 (Residues: 1-475; Coverage: 100%)
Gene name: ACP_2665
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand VGO 1 x VGO
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Unit cell:
a: 82.999Å b: 44.658Å c: 137.023Å
α: 90° β: 97.46° γ: 90°
R-values:
R R work R free
0.197 0.194 0.244
Expression system: Escherichia coli BL21(DE3)

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