› 8oh2

Electron Microscopy
2.6Å resolution

Structure of the Tau-PAM4 Type 1 amyloid fibril

Released:
DOI: 10.2210/pdb8oh2/pdb
PDB entry 8oh2 coloured by chain, front view.
PDB entry 8oh2 coloured by chain, side view.
PDB entry 8oh2 coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Local structural preferences in shaping tau amyloid polymorphism.
Louros N, Wilkinson M, Tsaka G, Ramakers M, Morelli C, Garcia T, Gallardo R, D'Haeyer S, Goossens V, Audenaert D, Thal DR, Mackenzie IR, Rademakers R, Ranson NA, Radford SE, Rousseau F, Schymkowitz J
OpenAccess logo Nat Commun 15 1028 (2024)
PMID: 38310108
Related structures: EMD-16876

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo 36-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273149 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j
Length: 15 amino acids
Theoretical weight: 1.44 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 666-680; Coverage: 2%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-16876
Expression system: Not provided

Quick links

Citations

1 review citation

The advent of preventive high-resolution structural histopathology by artificial-intelligence-powered cryogenic electron tomography.
Galaz-Montoya JG. (2024)
1 other article