› 8oin

Electron Microscopy
3.6Å resolution

55S mammalian mitochondrial ribosome with mtRF1 and P-site tRNA

Released:
DOI: 10.2210/pdb8oin/pdb
PDB entry 8oin coloured by chain, front view.
PDB entry 8oin coloured by chain, side view.
PDB entry 8oin coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
Saurer M, Leibundgut M, Nadimpalli HP, Scaiola A, Schönhut T, Lee RG, Siira SJ, Rackham O, Dreos R, Lenarčič T, Kummer E, Gatfield D, Filipovska A, Ban N
Science 380 531-536 (2023)
PMID: 37141370
Related structures: EMD-16894

Function and Biology Details

Reaction catalysed: 
N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 94-mer (preferred)
PDBe Complex ID:
PDB-CPX-236632 (preferred)
Entry contents:
83 distinct polypeptide molecules
6 distinct RNA molecules
Macromolecules (89 distinct):
39S ribosomal protein L12, mitochondrial Chains: B1, B2, B3, B4, B5, B6
Molecule details ›
Chains: B1, B2, B3, B4, B5, B6
Length: 198 amino acids
Theoretical weight: 21.27 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D0VGD9 (Residues: 1-198; Coverage: 100%)
Gene name: MRPL12
Sequence domains:
Large ribosomal subunit protein uL22m Chain: BA
Molecule details ›
Chain: BA
Length: 210 amino acids
Theoretical weight: 24.31 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1TXR4 (Residues: 1-210; Coverage: 100%)
Gene name: MRPL22
Sequence domains: Ribosomal protein L22p/L17e
Large ribosomal subunit protein uL23m Chain: BB
Molecule details ›
Chain: BB
Length: 150 amino acids
Theoretical weight: 17.69 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A480JJI1 (Residues: 1-150; Coverage: 100%)
Gene name: MRPL23
Sequence domains: Ribosomal protein L23
Large ribosomal subunit protein uL24m Chain: BC
Molecule details ›
Chain: BC
Length: 216 amino acids
Theoretical weight: 24.89 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RHJ1 (Residues: 1-216; Coverage: 100%)
Gene name: MRPL24
Sequence domains:
39S ribosomal protein L27, mitochondrial Chain: BD
Molecule details ›
Chain: BD
Length: 148 amino acids
Theoretical weight: 15.94 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1U0F6 (Residues: 1-148; Coverage: 100%)
Gene name: MRPL27
Sequence domains: Ribosomal L27 protein
Large ribosomal subunit protein bL28m Chain: BE
Molecule details ›
Chain: BE
Length: 256 amino acids
Theoretical weight: 30.15 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZTW8 (Residues: 1-256; Coverage: 100%)
Gene name: MRPL28
Sequence domains: Ribosomal L28 family
Large ribosomal subunit protein uL29m Chain: BF
Molecule details ›
Chain: BF
Length: 250 amino acids
Theoretical weight: 29.89 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SGC7 (Residues: 1-250; Coverage: 100%)
Gene name: MRPL47
Sequence domains: Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
Large ribosomal subunit protein uL30m Chain: BG
Molecule details ›
Chain: BG
Length: 161 amino acids
Theoretical weight: 18.92 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D0VJF4 (Residues: 1-161; Coverage: 100%)
Sequence domains: Ribosomal protein L30p/L7e
Large ribosomal subunit protein bL32m Chain: BH
Molecule details ›
Chain: BH
Length: 207 amino acids
Theoretical weight: 23.57 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LTC4 (Residues: 1-207; Coverage: 100%)
Gene name: MRPL32
Sequence domains: Ribosomal L32p protein family
Large ribosomal subunit protein bL33m Chain: BI
Molecule details ›
Chain: BI
Length: 65 amino acids
Theoretical weight: 7.51 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1TLP9 (Residues: 1-65; Coverage: 100%)
Gene name: MRPL33
Sequence domains: Ribosomal protein L33
Large ribosomal subunit protein bL34m Chain: BJ
Molecule details ›
Chain: BJ
Length: 95 amino acids
Theoretical weight: 10.87 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1JE64 (Residues: 1-95; Coverage: 100%)
Gene name: MRPL34
Sequence domains: Ribosomal protein L34
Large ribosomal subunit protein bL35m Chain: BK
Molecule details ›
Chain: BK
Length: 188 amino acids
Theoretical weight: 21.55 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A5G2QZK0 (Residues: 1-188; Coverage: 100%)
Gene name: MRPL35
Sequence domains: Ribosomal protein L35
Large ribosomal subunit protein uL2 C-terminal domain-containing protein Chain: BL
Molecule details ›
Chain: BL
Length: 306 amino acids
Theoretical weight: 33.27 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287A143 (Residues: 1-306; Coverage: 100%)
Gene name: MRPL2
Sequence domains:
Large ribosomal subunit protein uL3m Chain: BM
Molecule details ›
Chain: BM
Length: 399 amino acids
Theoretical weight: 43.71 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A140UHW4 (Residues: 1-399; Coverage: 100%)
Gene name: MRPL3
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein uL4m Chain: BN
Molecule details ›
Chain: BN
Length: 294 amino acids
Theoretical weight: 33.25 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287B9C4 (Residues: 1-250; Coverage: 92%)
Gene name: MRPL4
Sequence domains: Ribosomal protein L4/L1 family
Large ribosomal subunit protein bL9m Chain: BO
Molecule details ›
Chain: BO
Length: 268 amino acids
Theoretical weight: 30.37 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LR45 (Residues: 1-268; Coverage: 100%)
Gene name: MRPL9
Sequence domains:
Large ribosomal subunit protein uL10m Chain: BP
Molecule details ›
Chain: BP
Length: 257 amino acids
Theoretical weight: 29.24 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RWJ0 (Residues: 1-257; Coverage: 100%)
Gene name: MRPL10
Sequence domains: Ribosomal protein L10
Large ribosomal subunit protein uL11m Chain: BQ
Molecule details ›
Chain: BQ
Length: 192 amino acids
Theoretical weight: 20.81 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RU54 (Residues: 1-41, 42-160; Coverage: 100%)
Gene name: MRPL11
Sequence domains: Ribosomal protein L11, RNA binding domain
39S ribosomal protein L13, mitochondrial Chain: BR
Molecule details ›
Chain: BR
Length: 197 amino acids
Theoretical weight: 22.99 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: K7GP19 (Residues: 1-197; Coverage: 100%)
Gene name: MRPL13
Sequence domains: Ribosomal protein L13
Large ribosomal subunit protein uL14m Chain: BS
Molecule details ›
Chain: BS
Length: 325 amino acids
Theoretical weight: 34.8 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287BMZ6 (Residues: 1-325; Coverage: 100%)
Gene name: MRPL14
Sequence domains: Ribosomal protein L14p/L23e
Large ribosomal subunit protein uL15m Chain: BT
Molecule details ›
Chain: BT
Length: 296 amino acids
Theoretical weight: 33.48 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D0HMG9 (Residues: 1-296; Coverage: 100%)
Gene name: MRPL15
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein uL16m Chain: BU
Molecule details ›
Chain: BU
Length: 251 amino acids
Theoretical weight: 28.68 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RI89 (Residues: 1-251; Coverage: 100%)
Gene name: MRPL16
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein bL17m Chain: BV
Molecule details ›
Chain: BV
Length: 169 amino acids
Theoretical weight: 19.27 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RMQ4 (Residues: 1-169; Coverage: 100%)
Gene name: MRPL17
Sequence domains: Ribosomal protein L17
39S ribosomal protein L18, mitochondrial Chain: BW
Molecule details ›
Chain: BW
Length: 188 amino acids
Theoretical weight: 21.42 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1VX01 (Residues: 1-188; Coverage: 100%)
Gene name: MRPL18
Sequence domains: Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast
Large ribosomal subunit protein bL19m Chain: BX
Molecule details ›
Chain: BX
Length: 303 amino acids
Theoretical weight: 34.53 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LNJ0 (Residues: 1-303; Coverage: 100%)
Gene name: MRPL19
Sequence domains: Ribosomal protein L19
39S ribosomal protein L20, mitochondrial isoform 1 Chain: BY
Molecule details ›
Chain: BY
Length: 149 amino acids
Theoretical weight: 17.55 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZU56 (Residues: 1-149; Coverage: 100%)
Gene name: MRPL20
Sequence domains: Ribosomal protein L20
Large ribosomal subunit protein bL21m Chain: BZ
Molecule details ›
Chain: BZ
Length: 209 amino acids
Theoretical weight: 23.15 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RY70 (Residues: 1-209; Coverage: 100%)
Sequence domains: Ribosomal prokaryotic L21 protein
Large ribosomal subunit protein mL52 Chain: Ba
Molecule details ›
Chain: Ba
Length: 160 amino acids
Theoretical weight: 17.99 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1S9B7 (Residues: 1-160; Coverage: 100%)
Gene name: MRPL52
Sequence domains: Mitoribosomal protein mL52
Large ribosomal subunit protein mL53 Chain: Bb
Molecule details ›
Chain: Bb
Length: 112 amino acids
Theoretical weight: 12.06 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D0LKT0 (Residues: 1-112; Coverage: 100%)
Sequence domains: 39S ribosomal protein L53/MRP-L53
Large ribosomal subunit protein mL54 Chain: Bc
Molecule details ›
Chain: Bc
Length: 138 amino acids
Theoretical weight: 15.96 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LN63 (Residues: 1-160; Coverage: 86%)
Gene name: MRPL54
Sequence domains: Mitochondrial ribosomal protein L37
Mitochondrial ribosomal protein L55 Chain: Bd
Molecule details ›
Chain: Bd
Length: 126 amino acids
Theoretical weight: 15.16 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1ULI6 (Residues: 1-126; Coverage: 100%)
Gene name: MRPL55
Sequence domains: Mitochondrial ribosomal protein L55
Mitochondrial ribosomal protein L57 Chain: Be
Molecule details ›
Chain: Be
Length: 102 amino acids
Theoretical weight: 12 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287BP93 (Residues: 1-102; Coverage: 100%)
Gene name: MRPL57
Sequence domains: Mitochondrial ribosome protein 63
Large ribosomal subunit protein mL62 Chain: Bf
Molecule details ›
Chain: Bf
Length: 205 amino acids
Theoretical weight: 23.55 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZJR2 (Residues: 1-205; Coverage: 100%)
Gene name: MRPL58
Sequence domains: RF-1 domain
Large ribosomal subunit protein mL64 Chain: Bg
Molecule details ›
Chain: Bg
Length: 222 amino acids
Theoretical weight: 25.82 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZXA6 (Residues: 1-222; Coverage: 100%)
Gene name: GADD45GIP1
Sequence domains: Growth arrest and DNA-damage-inducible proteins-interacting protein 1
Mitochondrial ribosomal protein S18A Chain: Bh
Molecule details ›
Chain: Bh
Length: 196 amino acids
Theoretical weight: 22.27 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RRH6 (Residues: 9-25, 26-181; Coverage: 95%)
Gene name: MRPS18A
Sequence domains: Ribosomal protein S18
Mitochondrial ribosomal protein S30 Chain: Bi
Molecule details ›
Chain: Bi
Length: 433 amino acids
Theoretical weight: 49.1 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A480QIM3 (Residues: 1-433; Coverage: 100%)
Gene name: MRPS30
Sequence domains: Mitochondrial 28S ribosomal protein S30 (PDCD9)
Large ribosomal subunit protein uL1m Chain: Bj
Molecule details ›
Chain: Bj
Length: 304 amino acids
Theoretical weight: 34.37 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287AF82 (Residues: 1-304; Coverage: 100%)
Gene name: MRPL1
Sequence domains: Ribosomal protein L1p/L10e family
Ribosomal protein Chain: Bl
Molecule details ›
Chain: Bl
Length: 100 amino acids
Theoretical weight: 10.84 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287A731 (Residues: 1-100; Coverage: 100%)
Gene name: MRPL36
Sequence domains: Ribosomal protein L36
Large ribosomal subunit protein mL37 Chain: Bm
Molecule details ›
Chain: Bm
Length: 423 amino acids
Theoretical weight: 47.92 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287BIV6 (Residues: 1-423; Coverage: 100%)
Gene name: MRPL37
Sequence domains: Mitochondrial 28S ribosomal protein S30 (PDCD9)
Large ribosomal subunit protein mL38 Chain: Bn
Molecule details ›
Chain: Bn
Length: 380 amino acids
Theoretical weight: 44.66 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RW03 (Residues: 1-380; Coverage: 100%)
Gene name: MRPL38
Sequence domains: Phosphatidylethanolamine-binding protein
TGS domain-containing protein Chain: Bo
Molecule details ›
Chain: Bo
Length: 334 amino acids
Theoretical weight: 38.52 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SHP6 (Residues: 1-303, 304-318; Coverage: 100%)
Gene name: MRPL39
Large ribosomal subunit protein mL40 Chain: Bp
Molecule details ›
Chain: Bp
Length: 162 amino acids
Theoretical weight: 19.41 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZP98 (Residues: 1-162; Coverage: 100%)
Gene name: MRPL40
Sequence domains: Mitochondrial ribosomal protein L28
39S ribosomal protein L41, mitochondrial Chain: Bq
Molecule details ›
Chain: Bq
Length: 135 amino acids
Theoretical weight: 15.07 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1BPA5 (Residues: 1-135; Coverage: 100%)
Sequence domains: Mitochondrial ribosomal protein L27
Large ribosomal subunit protein mL42 Chain: Br
Molecule details ›
Chain: Br
Length: 142 amino acids
Theoretical weight: 16.68 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287BQA1 (Residues: 1-142; Coverage: 100%)
Gene name: MRPL42
Sequence domains: Mitochondrial 28S ribosomal protein S32
Large ribosomal subunit protein mL43 Chain: Bs
Molecule details ›
Chain: Bs
Length: 159 amino acids
Theoretical weight: 17.62 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1S8U4 (Residues: 2-159; Coverage: 99%)
Sequence domains: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Large ribosomal subunit protein mL44 Chain: Bt
Molecule details ›
Chain: Bt
Length: 332 amino acids
Theoretical weight: 37.53 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SR64 (Residues: 1-332; Coverage: 100%)
Gene name: MRPL44
Sequence domains:
Large ribosomal subunit protein mL45 Chain: Bu
Molecule details ›
Chain: Bu
Length: 306 amino acids
Theoretical weight: 35.33 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LGM5 (Residues: 1-306; Coverage: 100%)
Gene name: MRPL45
Sequence domains: Tim44-like domain
Large ribosomal subunit protein mL46 Chain: Bv
Molecule details ›
Chain: Bv
Length: 279 amino acids
Theoretical weight: 32.22 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SRT0 (Residues: 1-279; Coverage: 100%)
Gene name: MRPL46
Sequence domains: 39S mitochondrial ribosomal protein L46
Small ribosomal subunit protein uS10 domain-containing protein Chain: Bw
Molecule details ›
Chain: Bw
Length: 269 amino acids
Theoretical weight: 29.94 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A480J9Z6 (Residues: 1-269; Coverage: 100%)
Gene name: MRPL48
Sequence domains: Ribosomal protein S10p/S20e
Large ribosomal subunit protein mL49 Chain: Bx
Molecule details ›
Chain: Bx
Length: 166 amino acids
Theoretical weight: 18.96 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A0R4J8D6 (Residues: 1-122, 123-129; Coverage: 94%)
Gene name: MRPL49
Sequence domains: Mitochondrial large subunit ribosomal protein (Img2)
Large ribosomal subunit protein mL50 Chain: By
Molecule details ›
Chain: By
Length: 198 amino acids
Theoretical weight: 22.79 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3L9H6 (Residues: 1-198; Coverage: 100%)
Gene name: MRPL50
Sequence domains: Ribosomal subunit 39S
Large ribosomal subunit protein mL51 Chain: Bz
Molecule details ›
Chain: Bz
Length: 128 amino acids
Theoretical weight: 15.25 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1VKN8 (Residues: 1-128; Coverage: 100%)
Sequence domains: Mitochondrial ribosomal subunit
Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein Chain: AB
Molecule details ›
Chain: AB
Length: 366 amino acids
Theoretical weight: 41.36 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SG95 (Residues: 1-366; Coverage: 100%)
Gene name: MRPS35
Sequence domains: Mitochondrial ribosomal subunit protein
Mitochondrial ribosomal protein S24 Chain: AC
Molecule details ›
Chain: AC
Length: 167 amino acids
Theoretical weight: 18.94 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287ANU4 (Residues: 1-167; Coverage: 100%)
Gene name: MRPS24
Sequence domains: Mitochondrial ribosome subunit S24
Small ribosomal subunit protein mS38 Chain: AD
Molecule details ›
Chain: AD
Length: 199 amino acids
Theoretical weight: 22.84 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1P8R7 (Residues: 1-199; Coverage: 100%)
Gene name: AURKAIP1
Sequence domains: Mitochondrial mRNA-processing protein COX24, C-terminal
Small ribosomal subunit protein bS6m Chain: AE
Molecule details ›
Chain: AE
Length: 124 amino acids
Theoretical weight: 14.28 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A5K1V0G5 (Residues: 1-124; Coverage: 100%)
Sequence domains: Ribosomal protein S6
Small ribosomal subunit protein uS7m Chain: AF
Molecule details ›
Chain: AF
Length: 242 amino acids
Theoretical weight: 28.15 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZJ25 (Residues: 1-242; Coverage: 100%)
Gene name: MRPS7
Sequence domains: Ribosomal protein S7p/S5e
Small ribosomal subunit protein uS10m Chain: AH
Molecule details ›
Chain: AH
Length: 200 amino acids
Theoretical weight: 23.11 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RUU2 (Residues: 1-200; Coverage: 100%)
Gene name: MRPS10
Sequence domains: Ribosomal protein S10p/S20e
Small ribosomal subunit protein uS12m Chain: AJ
Molecule details ›
Chain: AJ
Length: 139 amino acids
Theoretical weight: 15.26 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A0M3KL52 (Residues: 1-139; Coverage: 100%)
Sequence domains: Ribosomal protein S12/S23
Mitochondrial ribosomal protein S14 Chain: AK
Molecule details ›
Chain: AK
Length: 128 amino acids
Theoretical weight: 15.12 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A0M3KL53 (Residues: 1-128; Coverage: 100%)
Gene name: MRPS14
Sequence domains: Ribosomal protein S14p/S29e
Small ribosomal subunit protein uS15m Chain: AL
Molecule details ›
Chain: AL
Length: 259 amino acids
Theoretical weight: 29.6 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287AKS1 (Residues: 1-259; Coverage: 100%)
Gene name: MRPS15
Sequence domains: Ribosomal protein S15
Small ribosomal subunit protein bS16m Chain: AM
Molecule details ›
Chain: AM
Length: 135 amino acids
Theoretical weight: 15.18 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A480JTD7 (Residues: 1-135; Coverage: 100%)
Sequence domains: Ribosomal protein S16
28S ribosomal protein S17, mitochondrial Chain: AN
Molecule details ›
Chain: AN
Length: 130 amino acids
Theoretical weight: 14.45 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1IXU1 (Residues: 1-130; Coverage: 100%)
Sequence domains: Ribosomal protein S17
Small ribosomal subunit protein mS40 Chain: AO
Molecule details ›
Chain: AO
Length: 258 amino acids
Theoretical weight: 29.22 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q767K8 (Residues: 1-258; Coverage: 100%)
Gene name: MRPS18B
Sequence domains: Ribosomal protein S18
Mitochondrial ribosomal protein S18C Chain: AP
Molecule details ›
Chain: AP
Length: 143 amino acids
Theoretical weight: 16.21 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A0M3KL54 (Residues: 1-143; Coverage: 100%)
Gene name: MRPS18C
Sequence domains: Ribosomal protein S18
28S ribosomal protein S21, mitochondrial Chain: AQ
Molecule details ›
Chain: AQ
Length: 87 amino acids
Theoretical weight: 10.72 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZNB3 (Residues: 1-87; Coverage: 100%)
Gene name: MRPS21
Sequence domains: Ribosomal protein S21
Mitochondrial ribosomal protein S22 Chain: AR
Molecule details ›
Chain: AR
Length: 382 amino acids
Theoretical weight: 43.23 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287AQT5 (Residues: 1-382; Coverage: 100%)
Gene name: MRPS22
Sequence domains: Mitochondrial 28S ribosomal protein S22
Small ribosomal subunit protein mS23 conserved domain-containing protein Chain: AS
Molecule details ›
Chain: AS
Length: 190 amino acids
Theoretical weight: 21.67 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287AEW3 (Residues: 17-207; Coverage: 91%)
Gene name: MRPS23
Sequence domains: Mitochondrial ribosomal protein S23
Small ribosomal subunit protein mS25 Chain: AT
Molecule details ›
Chain: AT
Length: 173 amino acids
Theoretical weight: 19.95 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A0M3KL55 (Residues: 1-173; Coverage: 100%)
Gene name: MRPS25
Sequence domains: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Progonadoliberin Chain: AU
Molecule details ›
Chain: AU
Length: 205 amino acids
Theoretical weight: 23.64 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287AY01 (Residues: 54-77; Coverage: 22%)
Gene name: GNRH2
Mitochondrial ribosomal protein S27 Chain: AV
Molecule details ›
Chain: AV
Length: 395 amino acids
Theoretical weight: 45.76 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A5G2R1I0 (Residues: 1-395; Coverage: 100%)
Gene name: MRPS27
Sequence domains: Mitochondrial 28S ribosomal protein S27
28S ribosomal protein S28, mitochondrial Chain: AW
Molecule details ›
Chain: AW
Length: 188 amino acids
Theoretical weight: 21.01 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A0M3KL56 (Residues: 1-188; Coverage: 100%)
Gene name: MRPS28
Sequence domains: Mitochondrial ribosomal protein MRP-S35
Small ribosomal subunit protein mS29 Chain: AX
Molecule details ›
Chain: AX
Length: 410 amino acids
Theoretical weight: 46.97 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1XNL0 (Residues: 1-410; Coverage: 100%)
Gene name: DAP3
Sequence domains: Mitochondrial ribosomal death-associated protein 3
Small ribosomal subunit protein mS31 Chain: AY
Molecule details ›
Chain: AY
Length: 381 amino acids
Theoretical weight: 43.52 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RME2 (Residues: 1-381; Coverage: 100%)
Gene name: MRPS31
Sequence domains: Mitochondrial 28S ribosomal protein S31
Small ribosomal subunit protein mS33 Chain: AZ
Molecule details ›
Chain: AZ
Length: 148 amino acids
Theoretical weight: 16.97 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1V2H3 (Residues: 1-148; Coverage: 100%)
Gene name: MRPS33
Sequence domains: Mitochondrial ribosomal subunit S27
Peptide chain release factor 1, mitochondrial Chain: Aa
Molecule details ›
Chain: Aa
Length: 474 amino acids
Theoretical weight: 55.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75570 (Residues: 1-445; Coverage: 100%)
Gene name: MTRF1
Sequence domains:
Mitochondrial ribosomal protein S2 Chain: Ab
Molecule details ›
Chain: Ab
Length: 289 amino acids
Theoretical weight: 31.73 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1S001 (Residues: 1-289; Coverage: 100%)
Gene name: MRPS2
Sequence domains: Ribosomal protein S2
CHCH domain-containing protein Chain: Ac
Molecule details ›
Chain: Ac
Length: 118 amino acids
Theoretical weight: 13.6 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1SZV4 (Residues: 1-118; Coverage: 100%)
Gene name: CHCHD1
Sequence domains: CHCH domain
Small ribosomal subunit protein uS5m Chain: Ad
Molecule details ›
Chain: Ad
Length: 430 amino acids
Theoretical weight: 48.21 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SU66 (Residues: 1-430; Coverage: 100%)
Gene name: MRPS5
Sequence domains:
Small ribosomal subunit protein mS39 Chain: Ae
Molecule details ›
Chain: Ae
Length: 692 amino acids
Theoretical weight: 78.52 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: K7GKS8 (Residues: 1-546, 547-690; Coverage: 100%)
Gene name: PTCD3
Sequence domains:
28S ribosomal protein S9, mitochondrial Chain: Ag
Molecule details ›
Chain: Ag
Length: 397 amino acids
Theoretical weight: 45.6 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LU08 (Residues: 1-397; Coverage: 100%)
Gene name: MRPS9
Sequence domains: Ribosomal protein S9/S16
Mitochondrial ribosomal protein S11 Chain: Ai
Molecule details ›
Chain: Ai
Length: 196 amino acids
Theoretical weight: 20.86 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZJJ6 (Residues: 1-196; Coverage: 100%)
Gene name: MRPS11
Sequence domains: Ribosomal protein S11
Mitochondrial ribosomal protein S34 Chain: Aj
Molecule details ›
Chain: Aj
Length: 505 amino acids
Theoretical weight: 55.71 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287AVS9 (Residues: 1-505; Coverage: 100%)
Gene name: MRPS34
Sequence domains: Mitochondrial 28S ribosomal protein S34
E-site tRNA Chain: B7
Molecule details ›
Chain: B7
Length: 3 nucleotides
Theoretical weight: 895 Da
16S ribosomal RNA Chain: B8
Molecule details ›
Chain: B8
Length: 1571 nucleotides
Theoretical weight: 504.91 KDa
Sequence domains: Bacterial large subunit ribosomal RNA
CP Phe-tRNA Chain: B9
Molecule details ›
Chain: B9
Length: 73 nucleotides
Theoretical weight: 23.52 KDa
Sequence domains: tRNA
12S rRNA Chain: AA
Molecule details ›
Chain: AA
Length: 960 nucleotides
Theoretical weight: 308.45 KDa
Sequence domains: Bacterial small subunit ribosomal RNA
P-site Met-tRNA(fMet) Chain: AG
Molecule details ›
Chain: AG
Length: 71 nucleotides
Theoretical weight: 22.66 KDa
Messenger RNA Chain: AI
Molecule details ›
Chain: AI
Length: 9 nucleotides
Theoretical weight: 2.9 KDa

Ligands and Environments

10 bound ligands:
Ligand MG 332 x MG
Ligand K 41 x K
Ligand PHE 1 x PHE
Ligand ZN 3 x ZN
Ligand FES 3 x FES
Ligand SPM 1 x SPM
Ligand SPD 1 x SPD
Ligand FME 1 x FME
Ligand ATP 1 x ATP
Ligand GDP 1 x GDP
11 modified residues:
Ligand 1MA 1 x 1MA
Ligand OMG 2 x OMG
Ligand OMU 1 x OMU
Ligand PSU 1 x PSU
Ligand MIA 1 x MIA
Ligand AYA 4 x AYA
Ligand SAC 1 x SAC
Ligand 5MU 1 x 5MU
Ligand B8T 1 x B8T
Ligand 5MC 1 x 5MC
Ligand MA6 2 x MA6

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-16894
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Decoding the Enigma: Translation Termination in Human Mitochondria.
Krüger et al. (2024)
1 more