Function and Biology

HSV-1 DNA polymerase-processivity factor complex in exonuclease state

Source organism: Human alphaherpesvirus 1 strain KOS
Biochemical function: protein binding
Biological process: bidirectional double-stranded viral DNA replication
Cellular component: DNA polymerase complex

EC 3.1.26.4: Ribonuclease H

Reaction catalysed:
Endonucleolytic cleavage to 5'-phosphomonoester.
Systematic name:
-
Alternative Name(s):
  • Calf thymus ribonuclease H
  • Endoribonuclease H
  • Endoribonuclease H (calf thymus)
  • Hybrid nuclease
  • Hybrid ribonuclease
  • Hybridase
  • Hybridase (ribonuclease H)
  • RNA*DNA hybrid ribonucleotidohydrolase
  • RNase H

EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

Sequence families

Pfam Protein families (Pfam)
PF02282
Domain description: DNA polymerase processivity factor (UL42)
Occurring in:
  1. DNA polymerase processivity factor
The deposited structure of PDB entry 8oja contains 2 copies of Pfam domain PF02282 (DNA polymerase processivity factor (UL42)) in DNA polymerase processivity factor. Showing 2 copies in chain B.

PF11590
Domain description: DNA polymerase catalytic subunit Pol
Occurring in:
  1. DNA polymerase catalytic subunit
The deposited structure of PDB entry 8oja contains 1 copy of Pfam domain PF11590 (DNA polymerase catalytic subunit Pol) in DNA polymerase catalytic subunit. Showing 1 copy in chain A.

PF00136
Domain description: DNA polymerase family B
Occurring in:
  1. DNA polymerase catalytic subunit
The deposited structure of PDB entry 8oja contains 1 copy of Pfam domain PF00136 (DNA polymerase family B) in DNA polymerase catalytic subunit. Showing 1 copy in chain A.

PF03104
Domain description: DNA polymerase family B, exonuclease domain
Occurring in:
  1. DNA polymerase catalytic subunit
The deposited structure of PDB entry 8oja contains 1 copy of Pfam domain PF03104 (DNA polymerase family B, exonuclease domain) in DNA polymerase catalytic subunit. Showing 1 copy in chain A.