› 8ojv

X-ray diffraction
2.1Å resolution

Crystal structure of the human IgD Fab - structure Fab4

Released:
DOI: 10.2210/pdb8ojv/pdb
PDB entry 8ojv coloured by chain, front view.
PDB entry 8ojv coloured by chain, side view.
PDB entry 8ojv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the human IgD Fab reveal insights into CH1 domain diversity.
Davies AM, Beavil RL, Barbolov M, Sandhar BS, Gould HJ, Beavil AJ, Sutton BJ, McDonnell JM
OpenAccess logo Mol Immunol 159 28-37 (2023)
PMID: 37267832

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-226553 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Human IgD Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 217 amino acids
Theoretical weight: 22.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Human IgD Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 227 amino acids
Theoretical weight: 25.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

3 bound ligands:
Ligand EDO 12 x EDO
Ligand PEG 2 x PEG
Ligand CL 1 x CL
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 57.774Å b: 71.645Å c: 131.633Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.216
Expression system: Homo sapiens

Quick links

Citations

3 review citations

A comprehensive overview of recent advances in generative models for antibodies.
Meng et al. (2024)
2 more