› 8olf

X-ray diffraction
1.45Å resolution

Carbonic Anhydrase IX like mutant in Complex with Steriod_Sulphamoyl inhibitor BS1982

Released:
DOI: 10.2210/pdb8olf/pdb
PDB entry 8olf coloured by chain, front view.
PDB entry 8olf coloured by chain, side view.
PDB entry 8olf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Brynda J, Rezacova PM, Kudova E

Function and Biology Details

Reactions catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Urea = cyanamide + H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133681 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chain: A
Molecule details ›
Chain: A
Length: 260 amino acids
Theoretical weight: 29.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand VS9 1 x VS9
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 41.84Å b: 41.18Å c: 71.91Å
α: 90° β: 103.88° γ: 90°
R-values:
R R work R free
0.157 0.156 0.177
Expression system: Escherichia coli

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