› 8omu

Electron Microscopy
3.43Å resolution

Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid in a low occupancy state

Released:
DOI: 10.2210/pdb8omu/pdb
PDB entry 8omu coloured by chain, front view.
PDB entry 8omu coloured by chain, side view.
PDB entry 8omu coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
OpenAccess logo Nat Struct Mol Biol (2023)
PMID: 37482561
Related structures: EMD-16977

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271669 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Solute carrier family 22 member 6 Chain: A
Molecule details ›
Chain: A
Length: 547 amino acids
Theoretical weight: 60.55 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O35956 (Residues: 1-541; Coverage: 98%)
Gene names: Oat1, Slc22a6
Sequence domains: Sugar (and other) transporter
Synthetic nanobody (Sybody) Chain: B
Molecule details ›
Chain: B
Length: 146 amino acids
Theoretical weight: 16.08 KDa
Source organism: synthetic construct
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.43Å
Relevant EMDB volumes: EMD-16977
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli

Quick links

Citations

2 review citations

Interplay between the Redox System and Renal Tubular Transport.
Wang et al. (2024)
1 more

1 mention without citation

Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Parker et al. (2023)