› 8ory

Solution NMR

Solution NMR structure of Notch1 L1740-1743 TMD

Released:
DOI: 10.2210/pdb8ory/pdb
PDB entry 8ory coloured by chain, ensemble of 40 models, front view.
PDB entry 8ory coloured by chain, ensemble of 40 models, side view.
PDB entry 8ory coloured by chain, ensemble of 40 models, top view.
Source organism: Homo sapiens
Primary publication:
Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by γ-Secretase.
Ortner M, Guschtschin-Schmidt N, Stelzer W, Muhle-Goll C, Langosch D
J Mol Biol 168218 (2023)
PMID: 37536392

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155479 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Notch 1 intracellular domain Chain: A
Molecule details ›
Chain: A
Length: 30 amino acids
Theoretical weight: 3.53 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P46531 (Residues: 1734-1757; Coverage: 1%)
Gene names: NOTCH1, TAN1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: simulated annealing
Expression system: Not provided

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