8osb

X-ray diffraction
2.9Å resolution

TWIST1-TCF4-ALX4 complex on specific DNA

Released:
Model geometry
Fit model/data

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-270618 (preferred)
Entry contents:
3 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (5 distinct):
Homeobox protein aristaless-like 4 Chain: E
Molecule details ›
Chain: E
Length: 62 amino acids
Theoretical weight: 7.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H161 (Residues: 216-277; Coverage: 15%)
Gene names: ALX4, KIAA1788
Sequence domains: Homeodomain
Transcription factor 4 Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 7.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15884 (Residues: 565-624; Coverage: 9%)
Gene names: BHLHB19, ITF2, SEF2, TCF4
Sequence domains: Helix-loop-helix DNA-binding domain
Twist-related protein 1 Chain: B
DNA (25-MER) Chain: X
DNA (25-MER) Chain: W

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P3121
Unit cell:
a: 60.589Å b: 60.589Å c: 237.289Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.22 0.27
Expression system: Escherichia coli