› 8otd

Electron Microscopy
2.6Å resolution

TMEM106B Fold1-s filament from Guam ALS/PDC

Released:
DOI: 10.2210/pdb8otd/pdb
PDB entry 8otd coloured by chain, front view.
PDB entry 8otd coloured by chain, side view.
PDB entry 8otd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
OpenAccess logo Proc Natl Acad Sci U S A 120 e2306767120 (2023)
PMID: 38100415
Related structures: EMD-17175

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242382 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein 106B Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 274 amino acids
Theoretical weight: 31.14 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NUM4 (Residues: 1-274; Coverage: 100%)
Gene name: TMEM106B
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-17175

Quick links

Citations

1 review citation

Tau and neurodegeneration.
Goedert et al. (2024)
1 other article