› 8otq

Electron Microscopy
3.22Å resolution

Cryo-EM structure of Strongylocentrotus purpuratus sperm-specific Na+/H+ exchanger SLC9C1 in GDN

Released:
DOI: 10.2210/pdb8otq/pdb
PDB entry 8otq coloured by chain, front view.
PDB entry 8otq coloured by chain, side view.
PDB entry 8otq coloured by chain, top view.
Source organism: Strongylocentrotus purpuratus
Primary publication:
Structure and electromechanical coupling of a voltage-gated Na+/H+ exchanger.
Yeo H, Mehta V, Gulati A, Drew D
Nature 623 193-201 (2023)
PMID: 37880360
Related structures: EMD-17182

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-233812 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sperm-specific sodium:proton exchanger Chains: A, B
Molecule details ›
Chains: A, B
Length: 1331 amino acids
Theoretical weight: 147.53 KDa
Source organism: Strongylocentrotus purpuratus
Expression system: Homo sapiens
UniProt:
  • Canonical: A3RL54 (Residues: 1-1325; Coverage: 100%)
Gene name: SLC9C1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CPL 2 x CPL
Ligand PLM 2 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.22Å
Relevant EMDB volumes: EMD-17182
Expression system: Homo sapiens

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