› 8ou4

X-ray diffraction
2.25Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-500380 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CULT domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 125 amino acids
Theoretical weight: 13.7 KDa
Source organism: Magnetospirillum gryphiswaldense
Expression system: Escherichia coli
UniProt:
  • Canonical: A4TVL0 (Residues: 1-124; Coverage: 100%)
Gene name: MGR_0879

Ligands and Environments

2 bound ligands:
Ligand ZN 3 x ZN
Ligand W2F 2 x W2F
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 56.511Å b: 59.542Å c: 88.185Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.268
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
Steinebach et al. (2023)