› 8owy

X-ray diffraction
3.2Å resolution

Crystal structure of METTL6 mutant 40-269 bound to SAH

Released:
DOI: 10.2210/pdb8owy/pdb
PDB entry 8owy coloured by chain, front view.
PDB entry 8owy coloured by chain, side view.
PDB entry 8owy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase.
Throll P, G Dolce L, Rico-Lastres P, Arnold K, Tengo L, Basu S, Kaiser S, Schneider R, Kowalinski E
Nat Struct Mol Biol (2024)
PMID: 38918637

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186185 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
tRNA N(3)-methylcytidine methyltransferase METTL6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 235 amino acids
Theoretical weight: 27.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TCB7 (Residues: 40-269; Coverage: 81%)
Gene name: METTL6
Sequence domains: Methyltransferase domain

Ligands and Environments

1 bound ligand:
Ligand SAH 2 x SAH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: C2
Unit cell:
a: 81.971Å b: 138.129Å c: 39.66Å
α: 90° β: 115.26° γ: 90°
R-values:
R R work R free
0.262 0.26 0.3
Expression system: Escherichia coli

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