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Crystal structure of human methionine aminopeptidase-2 complexed with (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl N-(trans-4-aminocyclohexyl)carbamate

Source organism: Homo sapiens
Biochemical function: metalloaminopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.11.18: Methionyl aminopeptidase

Reaction catalysed:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Systematic name:
-
Alternative Name(s):
  • L-methionine aminopeptidase
  • MAP
  • Methionine aminopeptidase
  • Peptidase M

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00557
Domain description: Metallopeptidase family M24
Occurring in:
  1. Methionine aminopeptidase 2
The deposited structure of PDB entry 8oxg contains 2 copies of Pfam domain PF00557 (Metallopeptidase family M24) in Methionine aminopeptidase 2. Showing 1 copy in chain B.

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