› 8p0a

Electron Microscopy
3.67Å resolution

Human Cohesin ATPase module

Released:
DOI: 10.2210/pdb8p0a/pdb
PDB entry 8p0a coloured by chain, front view.
PDB entry 8p0a coloured by chain, side view.
PDB entry 8p0a coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Landwerlin P, Durand A, Diebold-Durand M-L, Romier C
Related structures: EMD-17331

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-271759 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Structural maintenance of chromosomes protein 1A Chain: A
Molecule details ›
Chain: A
Length: 456 amino acids
Theoretical weight: 51.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14683 (Residues: 1-200, 992-1233; Coverage: 36%)
Gene names: DXS423E, KIAA0178, SB1.8, SMC1, SMC1A, SMC1L1
Sequence domains: RecF/RecN/SMC N terminal domain
Structural maintenance of chromosomes protein 3 Chain: B
Molecule details ›
Chain: B
Length: 462 amino acids
Theoretical weight: 52.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UQE7 (Residues: 1-961, 979-1217; Coverage: 37%)
Gene names: BAM, BMH, CSPG6, SMC3, SMC3L1
Sequence domains: RecF/RecN/SMC N terminal domain
64-kDa C-terminal product Chain: C
Molecule details ›
Chain: C
Length: 81 amino acids
Theoretical weight: 9.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60216 (Residues: 558-629; Coverage: 11%)
Gene names: HR21, KIAA0078, NXP1, RAD21, SCC1
Sequence domains: Conserved region of Rad21 / Rec8 like protein

Ligands and Environments

2 bound ligands:
Ligand ATP 2 x ATP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.67Å
Relevant EMDB volumes: EMD-17331
Expression system: Escherichia coli

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