› 8p0x

Electron Microscopy
7.5Å resolution

Structure of the human Commander complex Retriever Subcomplex

Released:
DOI: 10.2210/pdb8p0x/pdb
PDB entry 8p0x coloured by chain, front view.
PDB entry 8p0x coloured by chain, side view.
PDB entry 8p0x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and interactions of the endogenous human Commander complex.
Laulumaa S, Kumpula EP, Huiskonen JT, Varjosalo M
OpenAccess logo Nat Struct Mol Biol (2024)
PMID: 38459129
Related structures: EMD-17341

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-241862 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Coiled-coil domain-containing protein 93 Chain: K
Molecule details ›
Chain: K
Length: 631 amino acids
Theoretical weight: 73.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q567U6 (Residues: 1-631; Coverage: 100%)
Gene name: CCDC93
Sequence domains:
Coiled-coil domain-containing protein 22 Chain: L
Molecule details ›
Chain: L
Length: 627 amino acids
Theoretical weight: 70.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O60826 (Residues: 1-627; Coverage: 100%)
Gene names: CCDC22, CXorf37, JM1
Sequence domains:
Vacuolar protein sorting-associated protein 29 Chain: N
Molecule details ›
Chain: N
Length: 182 amino acids
Theoretical weight: 20.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UBQ0 (Residues: 1-182; Coverage: 100%)
Gene names: DC15, DC7, MDS007, VPS29
Sequence domains: Calcineurin-like phosphoesterase superfamily domain
VPS35 endosomal protein-sorting factor-like Chain: O
Molecule details ›
Chain: O
Length: 963 amino acids
Theoretical weight: 109.7 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7Z3J2 (Residues: 1-963; Coverage: 100%)
Gene names: 101F10.2, C16orf62, VPS35L
Vacuolar protein sorting-associated protein 26C Chain: P
Molecule details ›
Chain: P
Length: 297 amino acids
Theoretical weight: 33.05 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O14972 (Residues: 1-297; Coverage: 100%)
Gene names: DCRA, DSCR3, DSCRA, VPS26C
Sequence domains: Vacuolar protein sorting-associated protein 26

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 7.5Å
Relevant EMDB volumes: EMD-17341

Quick links

Citations

1 mention without citation

Author Correction: Structure and interactions of the endogenous human Commander complex.
Laulumaa et al. (2024)