› 8p34

Electron Microscopy
2.61Å resolution

Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT

Released:
DOI: 10.2210/pdb8p34/pdb
PDB entry 8p34 coloured by chain, front view.
PDB entry 8p34 coloured by chain, side view.
PDB entry 8p34 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mutation ∆K281 in MAPT causes Pick's disease.
Schweighauser M, Garringer HJ, Klingstedt T, Nilsson KPR, Masuda-Suzukake M, Murrell JR, Risacher SL, Vidal R, Scheres SHW, Goedert M, Ghetti B, Newell KL
OpenAccess logo Acta Neuropathol (2023)
PMID: 37351604
Related structures: EMD-17383

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145370 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chain: A
Molecule details ›
Chain: A
Length: 94 amino acids
Theoretical weight: 10.14 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 602-695; Coverage: 12%)
  • Best match: P10636-2 (Residues: 196-289)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.61Å
Relevant EMDB volumes: EMD-17383

Quick links

Citations

2 review citations

Tau and neurodegeneration.
Goedert et al. (2024)
1 more

1 mention without citation

Enhancing cryo-EM structure prediction with DeepTracer and AlphaFold2 integration.
Chen et al. (2024)