› 8p45

X-ray diffraction
3.23Å resolution

Crystal structure of human STING in complex with the agonist MD1202D

Released:
DOI: 10.2210/pdb8p45/pdb
PDB entry 8p45 coloured by chain, front view.
PDB entry 8p45 coloured by chain, side view.
PDB entry 8p45 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function.
Klima M, Dejmek M, Duchoslav V, Eisenreichova A, Sala M, Chalupsky K, Chalupska D, Novotná B, Birkuš G, Nencka R, Boura E
Structure (2024)
PMID: 38325369

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 204 amino acids
Theoretical weight: 23.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86WV6 (Residues: 140-343; Coverage: 54%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173

Ligands and Environments

1 bound ligand:
Ligand WY8 1 x WY8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2
Unit cell:
a: 89.49Å b: 77.98Å c: 35.42Å
α: 90° β: 97.58° γ: 90°
R-values:
R R work R free
0.209 0.207 0.259
Expression system: Escherichia coli BL21(DE3)

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