› 8p5g

X-ray diffraction
2.02Å resolution

Kinase domain of wild type human ULK1 in complex with compound CCT241533

Released:
DOI: 10.2210/pdb8p5g/pdb
PDB entry 8p5g coloured by chain, front view.
PDB entry 8p5g coloured by chain, side view.
PDB entry 8p5g coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Battista T, Semrau MS, Heroux A, Lolli G, Storici P

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130938 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase ULK1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 284 amino acids
Theoretical weight: 32.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75385 (Residues: 1-283; Coverage: 27%)
Gene names: KIAA0722, ULK1
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand XBJ 2 x XBJ
Ligand MG 4 x MG
Ligand NA 2 x NA
1 modified residue:
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 11.2C
Spacegroup: P21212
Unit cell:
a: 95.8Å b: 111.67Å c: 84.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.227
Expression system: Escherichia coli

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