› 8p7g

Solution NMR

Structural characterization of PHOX2B and its DNA interactions shed lights into the molecular basis of the + 7Ala variant pathogenicity in CCHS

Released:
DOI: 10.2210/pdb8p7g/pdb
PDB entry 8p7g coloured by chain, ensemble of 20 models, front view.
PDB entry 8p7g coloured by chain, ensemble of 20 models, side view.
PDB entry 8p7g coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterization of PHOX2B and its DNA interaction shed light on the molecular basis of the +7Ala variant pathogenicity in CCHS.
Diana D, Pirone L, Russo L, D'Abrosca G, Madheswaran M, Benfante R, Di Lascio S, Caldinelli L, Fornasari D, Acconcia C, Corvino A, Ventserova N, Pollegioni L, Isernia C, Di Gaetano S, Malgieri G, Pedone EM, Fattorusso R
Chem Sci 15 8858-8872 (2024)
PMID: 38873078

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275292 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Paired mesoderm homeobox protein 2B Chain: A
Molecule details ›
Chain: A
Length: 63 amino acids
Theoretical weight: 7.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q99453 (Residues: 98-158; Coverage: 19%)
Gene names: PHOX2B, PMX2B
Sequence domains: Homeodomain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 37%
Refinement method: na
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links