› 8p8q

X-ray diffraction
1.79Å resolution

Recombinant Ym1 crystal structure

Released:
DOI: 10.2210/pdb8p8q/pdb
PDB entry 8p8q coloured by chain, front view.
PDB entry 8p8q coloured by chain, side view.
PDB entry 8p8q coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Ym1 protein crystals promote type 2 immunity.
Heyndrickx I, Deswarte K, Verstraete K, Verschueren KHG, Smole U, Aegerter H, Dansercoer A, Hammad H, Savvides SN, Lambrecht BN
Elife 12 (2024)
PMID: 38194250

Function and Biology Details

Reaction catalysed: 
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128712 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chitinase-like protein 3 Chain: A
Molecule details ›
Chain: A
Length: 396 amino acids
Theoretical weight: 44.39 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: O35744 (Residues: 21-398; Coverage: 100%)
Gene names: Chi3l3, Chil3, Ym1
Sequence domains: Glycosyl hydrolases family 18

Ligands and Environments

2 bound ligands:
Ligand ACT 1 x ACT
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21
Unit cell:
a: 50.331Å b: 60.009Å c: 60.115Å
α: 90° β: 94.66° γ: 90°
R-values:
R R work R free
0.174 0.173 0.199
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Eosinophils as drivers of bacterial immunomodulation and persistence.
Parrish et al. (2024)
3 other articles